More than the sum: How does a composite interface govern function at the cell surface?

Alba Diz-Muñoz (EMBL, Heidelberg)

Nov 24. 2022, 10:00 — 10:45

The cell surface of animal cells is a composite interface with several layers, the plasma membrane, the actomyosin cortex and a protein layer that binds them together. Biochemically and mechanically each of these layers differs.My group is taking an engineering-inspired approach, combined with traditional cell biology methods, to quantitatively measure and predict how the various mechanical layers at the surface of animal cells govern function. Together, our work identifies membrane-to-cortex attachment as a critical mechanotransducer in cells, and membrane-to-cortex distance as a key geometrical parameter that regulates protein activity at the cell surface. 

Further Information
ESI Boltzmann Lecture Hall
Associated Event:
Mathematical Methods for the Study of Self-organization in the Biological Sciences (Thematic Programme)
Pierre Degond (IMT)
Marie Doumic (Sorbonne U, Paris)
Anna Kicheva (ISTA, Klosterneuburg)
Sara Merino-Aceituno (U of Vienna)
Christian Schmeiser (U of Vienna)