Oscillatory behaviour of a bi-monomeric, nonlinear Becker-Döring type model for prion dynamics

Klemens Fellner (U Graz)

Nov 25. 2022, 10:00 — 10:45

Prions are able to self-propagate biological information through the transfer of structural information from a misfolded/infectious protein in a prion state to a protein in a non-prion state. Prions cause diseases like Creuzfeldt-Jakob. Prion-like mechanisms are associated to Alzheimer, Parkinson ans Huntington diseases. We present a fundamental bi-monomeric, nonlinear Becker-D\"oring type model, which aims to explain experiments in the lab of Human Rezaei showing sustained oscillatory behaviour over multiple hours. We exemplify a mechanism of  oscillatory behaviour and show numerical simulations. 

Further Information
Venue:
ESI Boltzmann Lecture Hall
Associated Event:
Mathematical Methods for the Study of Self-organization in the Biological Sciences (Thematic Programme)
Organizer(s):
Pierre Degond (IMT)
Marie Doumic (Sorbonne U, Paris)
Anna Kicheva (ISTA, Klosterneuburg)
Sara Merino-Aceituno (U Vienna)
Christian Schmeiser (U Vienna)