In this talk, I will give a brief overview of recent developments in modeling quantum interferometry in the framework of quantum field theory in curved space-times. On the one hand, this involves differential-geometric questions of how to formulate generally covariant equations that model the dynamics of massive and massless quantum systems with and without internal degrees of freedom, and how to model realistic experimental setups in the language of Lorentzian geometry. On the other hand, this involves the question of how rigorous algebraic formulation of quantum field theory can be used to derive explicit predictions for realistic scenarios, in particular for single-particle and multi-particle interferometry. Finally, time permitting, I will comment on open questions in this field, related, in particular, to the time-dependent gravitational fields.