Modelling Dupuytren Disorder: the impact of cell motility (and other parameters) on finger contracture

Raluca Eftimie (U Franche-Comte, Besancon)

Jan 27. 2026, 14:00 — 14:30

Dupuytren Disorder (DD) is a fibro-proliferative disorder characterised by fibrosis of palmar and digital fascia that leads to finger flexion deformities. It starts with a nodule in the palm, that can evolve into fibrous cords. Here, we present a s simple mathematical model that can reproduce the main tissue-level patterns of DD: nodules, nodular cords and non-nodular cords. We investigate the parameters that have the most impact on cord contraction, and show that the fibroblast-to-myofibroblast transition has a. major impact. Also, the amount of the injury signal required to trigger this transition seem to be important, and this aspect points towards a potential link to individual genetics. 

Further Information
Venue:
ESI Boltzmann Lecture Hall
Associated Event:
Modelling Diffusive Systems: Theory & Biological Applications (MoDiS) (Workshop)
Organizer(s):
Valeria Giunta (Swansea U)
Annalisa Iuorio (Parthenope U of Naples)
Angelika Manhart (U of Vienna)
Cinzia Soresina (U of Trento)