Evolutionary Advantage of Cell Size Control

Spencer Hobson-Gutierrez (NYU, New York)

Jun 11. 2025, 13:30 — 14:00

We analyze the advantage of cell size control strategies in growing populations under mortality constraints and show that growth-dependent mortality can select for accurate size control. We determine how mortality, noise, and nongenetic heritability of cell size impact long-term population growth. We derive an analytical expression for the optimal cell size. We demonstrate that size heritability enables selection to act on the distribution of cell sizes in a population to avoid viability thresholds and adapt to size- and growth-dependent mortality landscapes.

Further Information
Venue:
ESI Boltzmann Lecture Hall
Recordings:
Recording
Associated Event:
Extremal Statistics in Biology (Workshop)
Organizer(s):
Ariel Amir (Weizmann Institute, Rehovot)
Christoph Dellago (U of Vienna)
Ethan Levien (Dartmouth College)