Shear-Induced Dynamics and Mechanical Responses in Biological Tissues

Dapeng "Max" Bi (Northeastern)

Sep 10. 2024, 09:30 — 10:00

We will examine the dynamic mechanical responses of biological tissues to shear forces using computational models and theoretical frameworks. We begin with shear-driven solidification in epithelial tissues, demonstrating how a fluid-like tissue transitions to a solid-like state under strain and adopts nonlinear elastic behaviors at larger deformations. We then discuss discontinuous shear thickening observed in tissue rheology, emphasizing the interplay between externally applied and internally generated stresses during morphogenesis. Additionally, we explore the plastic response and avalanche dynamics in tissues under large deformations, showing how cells rearrange collectively in response to stress. Finally, we analyze the mechanical properties of multilayered skin epidermis under shear, including transitions from ductile to brittle responses based on interfacial tensions and cellular configurations. The talk aims to provide detailed insights into the mechanisms governing tissue mechanics, with implications for understanding developmental processes and designing bioengineered systems.

Further Information
Venue:
ESI Boltzmann Lecture Hall
Recordings:
Recording
Associated Event:
Linking Microscopic Processes to the Macroscopic Rheological Properties in Inert and Living Soft Materials (Thematic Programme)
Organizer(s):
Roberto Cerbino (U of Vienna)
Emanuela Del Gado (Georgetown U)
Giuseppe Foffi (Paris-Saclay U)