Chromatin is a highly dynamic and complex structure that undergoes changes in response to environmental cues. Even small changes at the atomistic level can lead to large perturbations in the overall chromatin structure and function due to its hierarchical organization with many levels of regulation. We study the roles of DNA and histone modifications in the precise regulation of chromatin compaction, DNA accessibility and binding of chromatin factors. Semi-quantitative experimental methods may offer context-specific information but often lack single-nucleotide and atomistic precision. Therefore to gain insights into chromatin dynamics at high resolution, we develop integrative approaches by combining experimental data with atomistic molecular dynamics simulations, machine learning and molecular modelling.