The rise of HiC chromosome capture methods has recently enabled low-resolution structures of interphase chromatin [1]. In this presentation I will explain how haploid [2] and diploid [3] structures based on single cell contact matrices are obtained from simulations of coarse-grained bead-spring polymer Go models. The role of knots which naturally occur in this process [2,4] will be critically assessed.
[1] T.J. Stevens et al, Nature 544, 59-64 (2017). [2] S. Wettermann et al, Comp. Mat. Sci 173, 109178 (2020). [3] J. Rothörl et al, Front. Bioinform. 3, 1284484 (2023). [4] J.T. Siebert et al, Polymers 9, 317 (2017).